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首页- Products - Others - Other Targets - PACMA 31

PACMA 31

CAS No. 1401089-31-3

PACMA 31 ( —— )

产品货号. M28353 CAS No. 1401089-31-3

PACMA 31 is an irreversible and covalent inhibitor of protein disulfide isomerase (PDI) with an IC50 of 10 μM. PACMA 31 significantly suppresses ovarian tumor growth and exhibits tumor targeting ability.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ￥478 有现货
5MG ￥786 有现货
10MG ￥1320 有现货
25MG ￥2940 有现货
50MG ￥4795 有现货
100MG ￥6901 有现货
500MG ￥14013 有现货
1G 获取报价 有现货
拼团 产品询价 大包装询价 加入购物车

生物学信息

  • 产品名称
    PACMA 31
  • 注意事项
    本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
  • 产品简述
    PACMA 31 is an irreversible and covalent inhibitor of protein disulfide isomerase (PDI) with an IC50 of 10 μM. PACMA 31 significantly suppresses ovarian tumor growth and exhibits tumor targeting ability.
  • 产品描述
    PACMA 31 is an irreversible and covalent inhibitor of protein disulfide isomerase (PDI) with an IC50 of 10 μM. PACMA 31 significantly suppresses ovarian tumor growth and exhibits tumor targeting ability.(In Vitro):In OVCAR-8 cells, PACMA 31 (0-10 μM) potently inhibits colony formation in a dose-dependent manner.(In Vivo):In human ovarian cancer mouse xenografts, PACMA 31 (20-200 mg/kg) i.p. or per os administration of significantly inhibited tumor growth by 85% and 65% at day 62, respectively.
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    P-gp
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    1401089-31-3
  • 分子量
    430.5
  • 分子式
    C21H22N2O6S
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    O=C(C#C)N(C1=CC=C(OC)C=C1OC)C(C(=O)NCC(=O)OCC)C=2SC=CC2
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Yuan S, et al. Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors. J Med Chem. 2021;64(19):14895-14911.
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