021-51111890
购物车（）
sales@molnova.cn
PACMA 31
CAS No. 1401089-31-3
PACMA 31 ( —— )
产品货号. M28353 CAS No. 1401089-31-3
PACMA 31 is an irreversible and covalent inhibitor of protein disulfide isomerase (PDI) with an IC50 of 10 μM. PACMA 31 significantly suppresses ovarian tumor growth and exhibits tumor targeting ability.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥478 | 有现货 |
|
| 5MG | ￥786 | 有现货 |
|
| 10MG | ￥1320 | 有现货 |
|
| 25MG | ￥2940 | 有现货 |
|
| 50MG | ￥4795 | 有现货 |
|
| 100MG | ￥6901 | 有现货 |
|
| 500MG | ￥14013 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称PACMA 31
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述PACMA 31 is an irreversible and covalent inhibitor of protein disulfide isomerase (PDI) with an IC50 of 10 μM. PACMA 31 significantly suppresses ovarian tumor growth and exhibits tumor targeting ability.
-
产品描述PACMA 31 is an irreversible and covalent inhibitor of protein disulfide isomerase (PDI) with an IC50 of 10 μM. PACMA 31 significantly suppresses ovarian tumor growth and exhibits tumor targeting ability.(In Vitro):In OVCAR-8 cells, PACMA 31 (0-10 μM) potently inhibits colony formation in a dose-dependent manner.(In Vivo):In human ovarian cancer mouse xenografts, PACMA 31 (20-200 mg/kg) i.p. or per os administration of significantly inhibited tumor growth by 85% and 65% at day 62, respectively.
-
同义词——
-
通路Others
-
靶点Other Targets
-
受体P-gp
-
研究领域——
-
适应症——
化学信息
-
CAS Number1401089-31-3
-
分子量430.5
-
分子式C21H22N2O6S
-
纯度>98% (HPLC)
-
溶解度——
-
SMILESO=C(C#C)N(C1=CC=C(OC)C=C1OC)C(C(=O)NCC(=O)OCC)C=2SC=CC2
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Yuan S, et al. Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors. J Med Chem. 2021;64(19):14895-14911.
产品手册
关联产品
-
Methyl nomilinate
Methyl nomilinate from citrus can modulate cell cycle regulators to induce cytotoxicity in human colon cancer (SW480) cells in vitro.
-
Euphorbia factor L25
Reference standards. Euphorbia factor L1 analogue.
-
Gabapentin enacarbil
Gabapentin enacarbil is a prodrug for the anticonvulsant and analgesic drug gabapentin.
